| Plast Reconstr Surg 1998 Dec;102(7):2404-7 |
Promotion of second intention wound healing
by emu oil lotion: comparative results with furasin, polysporin,
and cortisone.
Politis MJ, Dmytrowich A
Department of Medical Physiology at the University of Saskatchewan,
Saskatoon, Canada.
Previous studies showed that twice-daily application of emu
oil lotion (mixture of emu oil/fat, vitamin E, and botanical
oil) immediately after creation of full-thickness skin defects
delayed wound healing 6 days later, perhaps owing to its anti-inflammatory
actions. If administration was delayed for 48 hours, a two-fold
promotion of wound contraction, epithelialization, and infiltration
of organized granulation tissue was observed. In the present
study, emu oil lotion was applied to full-thickness skin defects
in rodents 24 hours after surgery. Six days postoperatively,
wound contraction and infiltration of fronts of epithelialized
and granulation tissue were assessed. Results indicated a two-fold
promotion of all of the above parameters with emu oil lotion.
No such effects were exerted by pure emu oil, furasin, cortaid,
or polysporin. Data obtained indicate promise for emu oil lotion
as an aid in treating full-thickness skin defects if applied
after the major post inflammatory stages of wound healing have
transpired.
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