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| Plast Reconstr Surg 1998 Dec;102(7):2404-7 |
Promotion of second intention wound healing
by emu oil lotion: comparative results with furasin, polysporin,
and cortisone.
Politis MJ, Dmytrowich A
Department of Medical Physiology at the University of Saskatchewan,
Saskatoon, Canada.
Previous studies showed that twice-daily application of emu oil
lotion (mixture of emu oil/fat, vitamin E, and botanical oil)
immediately after creation of full-thickness skin defects delayed
wound healing 6 days later, perhaps owing to its anti-inflammatory
actions. If administration was delayed for 48 hours, a two-fold
promotion of wound contraction, epithelialization, and infiltration
of organized granulation tissue was observed. In the present study,
emu oil lotion was applied to full-thickness skin defects in rodents
24 hours after surgery. Six days postoperatively, wound contraction
and infiltration of fronts of epithelialized and granulation tissue
were assessed. Results indicated a two-fold promotion of all of
the above parameters with emu oil lotion. No such effects were
exerted by pure emu oil, furasin, cortaid, or polysporin. Data
obtained indicate promise for emu oil lotion as an aid in treating
full-thickness skin defects if applied after the major post inflammatory
stages of wound healing have transpired.
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