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The RU 58841 Experiment
 
 
 
intro interview pictures before pictures after
 
Disclaimer - RU 58841 is an experimental drug and has not been approved for use in humans. In addition there is limited data available on its safety. We do not encourage or endorse the use of this experimental drug and this article is presented for information purposes only.
 

About this story

We were contacted by a person claiming to have gained access to a source of RU 58841 and was using it for treating his hair loss. We were interested in tracking his progress and he gave us permission to display his pictures and story on this site. He will be supplying us with updated information about his progress as time goes on.

 

About RU 58841

C L I N I C A L   S T U D I E S
RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism.
Local inhibition of sebaceous gland growth by topically applied RU 58841.
Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the postpubertal stumptailed macaque.
Importance of sebaceous glands in cutaneous penetration of an antiandrogen: target effect of liposomes.
Effects of topical antiandrogen and 5-alpha-reductase inhibitors on sebaceous glands in male fuzzy rats.
A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice.
Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques.
Roles of testosterone in the growth of keratinocytes through bald frontal dermal papilla cells.

RU 58841 is a very powerful topical anti-androgen originally developed by the Roussel Corporation of France.

One of the major problems with oral anti-androgens such as Spironolactone and Flutamide is that while they are good for hair loss, they can cause all sorts of problems related to having low androgens in your body, such as loss of muscle, increased fat, loss of sex drive, gyno, etc.

RU 58841 has been shown in animal studies to be extremely powerful as a topical anti-androgen with no systematic side effects.

RU 58841 was bought by the Aventis Drug company and it was scheduled to undergo testing as a hair loss drug. Unfortunately in 1999 the scheduled trials for alopecia were discontinued and Aventis has not shown an interest in bringing the drug to market.

This turn of events has created some frustration for hair loss sufferers and there have been a few reports of people having it custom made for them. This is not a simple process and can cost in excess of $20,000 for a small batch. We were recently contacted by someone who claimed to have gained access to a supply of this drug at great expense and had decided to start using it.

We have decided to follow his progress since this is the first time it has ever been documented in humans. We do not encourage taking this drug since it has not been approved or tested in humans. The individual, who we will call "John", has undertaken this course of action of his own free will and we are documenting his experiences for scientific purposes only.

 
Photographs showing effects of topical RU 58841 on hair regrowth in the bald frontal scalps of the stumptailed macaques.

Increased density and length of hairs were observed in a scalp at 4 months after treatment with 5% RU 58841 (b) compared with the scalp at the pretreatment time (a).

A slight increased density of hairs was noticed in a scalp at 4 months after treatment with 0.5% RU 58841 (d) compared with the scalp at the pretreatment time (c).

A vehicle-treated scalp showed no signs of hair regrowth (e, at the pretreatment time and f, at 4 months).
 
 
   
 
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