HAIRLOSSHELP: Lets talk about FNS. We have had much conflicting info on what's in it. First we were told it's the same as the original Piliel formula and then we are later told key hormones are not in the FNS formula. Please clarify what is different between FNS and the original Piliel that you developed.

DR. LINDENBAUM: FNS is essentially based on the same concept as Piliel. Some of the medium components were changed and some of the hormonal elements were eliminated following extensive reevaluation of each on the growth rate of hair in both in-vitro and in-vivo experiments.

HAIRLOSSHELP: If the formula is not true to the original one that you had results from, and this is the reason why LMS didn't get the same results in their trials, then how do you know FNS will be as effective as Piliel?

DR. LINDENBAUM: The reason LMS results differed from our results was due to the changes LMS made in the formulation they used in their trials. FNS formulation will follow our improved formulation and that will ensure its success.

HAIRLOSSHELP: What kinds of tests or studies have you done to verify this and please elaborate if possible?

DR. LINDENBAUM: We have tested it in two ways. Firstly extensive human hair organ cultures were performed to optimize the formulation. Our results in culture yielded hair growth rates that mimicked the rate of an in-vivo system. Secondly, our clinical trials on both men and women yielded satisfactory results.

HAIRLOSSHELP: When you say satisfactory can you be more specific like will FNS be able to halt hair loss in people with (MPB) and if so how does it work since it does not appear to be an anti-androgen?

DR. LINDENBAUM: Yes FNS was shown to stop the process of hair loss in volunteers suffering from androgenetic alopecia. The basic objective of the FNS treatment is to create a physiologically balanced nutrient-rich microenvironment in and around the hair follicle. This will ensure the availability of the required components for keratin synthesis in the follicular cells.

HAIRLOSSHELP: How did the female subjects in your trials respond to FNS and how old were they?

DR. LINDENBAUM: The results were very encouraging in women in both stopping the hair loss and in revitalizing the existing hair. Our volunteers who were between the ages of 45-70 were very satisfied with their results.

HAIRLOSSHELP: What is the longest time you have followed a subject who was using FNS?

DR. LINDENBAUM: Our clinical trials lasted over 2 years.

HAIRLOSSHELP: How effective were their results and did they slow after time?

DR. LINDENBAUM: The results showed cessation of hair loss, strengthening of the existing hair and increased rate of hair growth. The hair growth continued at a physiological rate throughout our trials.

HAIRLOSSHELP: Will FNS be able to reverse miniaturized hair follicles? And if so how successful do you think it will be in people who have functioning follicles but whose follicles are only capable of producing vellus or fine terminal hairs?

DR. LINDENBAUM: FNS strengthens and revitalizes the hair follicle cells. If the term "miniaturized hair follicle" is defined as hair follicle in the catagen/telogen phase of the hair cycle then FNS will stimulate it to revert to the anagen phase.

HAIRLOSSHELP: If someone wanted to continue using Minoxidil, how would they use it in addition to the FNS?

DR. LINDENBAUM: FNS is a stand-alone product for hair treatment. The combination of Minoxidil with FNS was not tested. However, there is no obvious conflict between FNS and Minoxidil since their mechanisms of action are entirely different.

HAIRLOSSHELP: Do you think there is a chance of the hairs growing from the effects of FNS then be unable to sustain their growth without it? i.e. They become dependent on FNS for their growth?

DR. LINDENBAUM: Our experience indicates that FNS will strengthen and invigorate the hair follicles. Eventually (6-12 months) a stage will be reached when the hair follicle is active at its optimal capacity. At that time it will be possible to discontinue the treatment and only use FNS as a booster once in a while depending on the individual condition of the user.

HAIRLOSSHELP: Do you believe FNS upregulates growth factors like VEGF, KGF, PDGF or if not how does it actually work?

DR. LINDENBAUM: FNS will upregulate all the growth factors synthesized and secreted by the hair follicular cells because the metabolic process of the follicular cells are upregulated by the availability of the nutrients, vitamins, electrolytes, trace elements and energy sources contained in FNS.

HAIRLOSSHELP: According to your patent, the original formula contained a mixture of non-steroidal anabolic hormones like insulin, triiodothyronine or thyroxine. Does the current formula contains these same hormones and if not what anabolic non-steroidal hormones does the formula contain?

DR. LINDENBAUM: The original formulation contained insulin, which transports amino acids and glucose across the cell membrane. Recent scientific discoveries have identified alternative compounds that have the same insulin-like properties. The final formulation for FNS will contain an ingredient that actively transports amino acids and glucose across cell membranes as effectively, if not more so, than the original formulation. The use of growth hormone and thyroxine was eliminated due to the minor role they play in augmenting the efficacy of the hair growth.

HAIRLOSSHELP: My understanding is that you used a standard cell culture medium when you first applied it to the girl's head that healed her wound. If this is common around labs then why did it not become a standard wound healing treatment if it was so successful at healing wounds?

DR. LINDENBAUM: The formulation used on the first patient (girl head) was an enriched cell culture medium optimized for wound healing. The wound healing formulation underwent extensive in-vitro and in-vivo studies prior to the clinical trials. Those results were published in scientific journals and are in the public domain. I do not know the reason it is not a standard wound healing treatment in spite of its obvious efficacy.

HAIRLOSSHELP: When can we expect the product to be available?

DR. LINDENBAUM: In about 4-6 weeks.