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  PROPECIA FDA HEARING  
 
 
QUESTION 2
 
How does Finasteride affect oiliness of the skin and acne
 
ANSWER

DR. TSCHEN: Was there any effect in these patients, any other methodological effect, as far as decrease in the oiliness of the skin, decrease in seborrhea or seborrheic dermatitis or acne? I know there are differences, but were these questions asked to these patients, if their acne was better or if their skin got drier?

DR. WALDSTRAICHER: Right; the question is whether we've asked about sebum production, oiliness of skin or acne in our clinical studies. We did a 6-week study looking at scalp-skin DHT levels, and in those same patients, on 6 weeks of finasteride at multiple doses, we also measured sebum output using sebatape, which is an established method, and we did not see a significant suppression of sebum output with finasteride.

We also have not observed any reports of acne worsening or improving in either group different from placebo.

 
   
 
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