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What is DHT?

A: Dihydrotestosterone (DHT) is produced from the male hormone testosterone by the enzyme 5-alpha reductase. DHT is the androgen thought to be most responsible for the type of hair loss also known as male pattern baldness. DHT has a very high affinity for the androgen receptor and is estimated to be five to ten times more potent than testosterone. Other androgens that may be significant in pattern loss include androstenedione, androstanedione and DHEA (especially in women). All of these fall into hormonal pathways that can potentially result in elevation of DHT downstream via various enzymes. It is possible that certain DHT metabolites may play a role in male pattern hair loss as well.

 

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