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What kind of side effects can you get with Propecia or other systemic DHT inhibitors?

A: Propecia (finasteride) is the best documented of the DHT inhibitors and most people notice no side effects from it. Some people do, however, experience a reduction in libido or notice more watery semen. Some get some noticeable hyperandrogenicity, as evidenced by increased facial oil, pimples or unusually high libido. Testicular ache is occasionally noted, probably due to increased testosterone output, and the body takes time to adjust to this. (Increased testosterone levels--15% on average in finasteride users--are likely in large part a compensatory response to reduced DHT.) Most often any side effects dissipate within 2 or 3 months. If they do not, things should return to normal after discontinuing finasteride, although this may take a couple of weeks, as finasteride has a relatively long biological effect, although a short serum half-life.

 

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