Dr Ken Washenik - Medical Director of the Aderans Research
was this procedure done and was it performed on one of their
this was a patient and it was done just over a year ago.
they been following the progression of this hair since this
the hair is gone. It was cut out and analyzed because of the
need for information so it was studied and not left in the
patient to grow.
it not be important to leave it in the patient's head to see
if it will cycle?
There is no doubt that the next step is to let hair continue
to grow. When it becomes routine to grow hair you won't be
so excited that you will want to remove the follicle and study
it. In the future it should happen in such a consistent fashion
that you could take half of the new follicles out and leave
the rest in and watch the hairs to see if they cycle. The
big question is what will happen after the 3-year cycle of
anagen, catagen and telogen, will it then go back into anagen
that experiment, what cells were used as the progenitor of
the hair follicle?
cells in that experiment were dermal papilla cells or dermal
that what they are using now in the current research?
current work involves looking at a number of different cell
types and combinations of cell types as opposed to just picking
one set of cell types. We are looking at what will most consistently
grow hair as opposed to what will once in a while grow hair.
it your personal opinion that it’s a combination or
cocktail of cells that will work best?
I think there has to be an exchange between the cells. What
we are really trying to do it to duplicate what happens when
hair follicles are first created in a fetus. And that happens
as a result of an interaction or exchange of cytokines, or
chemicals, between different cells. So chemicals are exchanged
between keratinocytes in the epidermis and the fibroblasts
in the dermis. They communicate back and forth and several
of those molecules have been identified and several have not.
And how you deliver those is a problem.
likely you are going to have to get those keratinocytes and
fibroblasts to communicate. So what’s the most sensible
way? One of the ways is getting those cells together to see
how much or what percentage you need of each of them. The
other possibility is can you introduce a pure population,
like in this case the fibroblasts of the dermal papilla and
have it communicate with keratinocytes that are already there.
And that’s what needs to be better studied. You may
need to place both together, or you may just need to have
one so it can communicate with the cells already in your skin.
what point in the development of the fetus does the development
of the hair follicle take place? And I know it’s a controversial
idea, but is there any way you can learn something from studying
Its more than controversial, it just cannot be done. It’s
very early in the pregnancy. And there is just no way it can
be done. But we should not need to; we should be able to learn
all we need from cell culture in a laboratory.
just thought that if they could examine the tissue at the
appropriate time of follicle formation, they could tell exactly
what was going on instead of just speculating.
that was actually done years and years ago by studying fetuses
that died at different time points so they pretty much know
the morphology, the histology and the anatomy of what’s
happening. The thing that you can’t tell is what chemical
exchange is going on. If you look at dermatology textbooks
the follicle formation is really well documented. Its starts
out where there is nothing, just flat skin, and then what
you have next is a condensation of cells in the dermis which
is really just a vague gathering of cells just under the flat
epidermis in what we call the ectoderm. So that’s called
the dermal condensation and that’s the very beginning
of the dermal papilla. And when that starts, its like the
chicken and egg scenario because no one is sure if the epidermis
dictates the formation of the condensation, or of the condensation
just occurs on its own and then starts to dictate to the epidermis.
But the first thing you can see morphologically in the formation
of a hair follicles is the condensation. Then you get what’s
called the bud formation which is just a downgrowth of skin
which is called the hair peg. This is a very early finger-like
indentation in the epidermis which grows down towards this
condensation of fibroblasts, and then that combines and gradually
matures into the dermal papilla and the hair follicle.
to Part 3