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Topic Title: Significant Updates for CB
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Created On: 10/07/2015 07:32 PM
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 10/07/2015 07:32 PM
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Billypcuc
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- CB-03-01 is now formally known as Breezula. A new company was formed that holds the rights to the related products (acne, HPV, etc). Cosmo still holds a significant stake in the company.

- Last subject first visit into the Breezula PII trial was in June. Last subject last visit should occur in December. The company could have data by years end, if not in January. They commit to a 1H16 release of data, but being a public company they will not be able to hold on to it too long without disclosing it to the public since it is material information

- I am not convinced the new entity will be able to pull off the financing to run another phase 3 program, which they apparently would have to do with their burn rate. They would either have to partner or go through another round of significant financing (and diluttion). This will likely mean additional time to the start of Phase 3. Most companies can move from phase 2 to the start of phase 3 within 6-8 months, assuming a successful end of phase 2 meeting with FDA. Although I hope that is the case here, I struggle to see this actually happening

- I have been quite lazy and selfish over the past year and have many other updates to provide when I can get around to it. Here is one:

If you are having significant sexual sides from fin/dut, then consume 1-2 servings beef protein powder. For responders, it works within a day...but warning, it will set your hair back with continued use...pretty much guaranteed. The effect is largely owed to creatine and it provide a weekend respite for those in need. Enjoy.
 10/07/2015 08:37 PM
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Eller
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Originally posted by: Billypcuc

- CB-03-01 is now formally known as Breezula. A new company was formed that holds the rights to the related products (acne, HPV, etc). Cosmo still holds a significant stake in the company.



- Last subject first visit into the Breezula PII trial was in June. Last subject last visit should occur in December. The company could have data by years end, if not in January. They commit to a 1H16 release of data, but being a public company they will not be able to hold on to it too long without disclosing it to the public since it is material information



- I am not convinced the new entity will be able to pull off the financing to run another phase 3 program, which they apparently would have to do with their burn rate. They would either have to partner or go through another round of significant financing (and diluttion). This will likely mean additional time to the start of Phase 3. Most companies can move from phase 2 to the start of phase 3 within 6-8 months, assuming a successful end of phase 2 meeting with FDA. Although I hope that is the case here, I struggle to see this actually happening



- I have been quite lazy and selfish over the past year and have many other updates to provide when I can get around to it. Here is one:



If you are having significant sexual sides from fin/dut, then consume 1-2 servings beef protein powder. For responders, it works within a day...but warning, it will set your hair back with continued use...pretty much guaranteed. The effect is largely owed to creatine and it provide a weekend respite for those in need. Enjoy.


Thanks for the update.

In response to your last comment... so you're saying, essentially, creatine will offset any significant sides from fin/dut? It takes weeks for creatine to saturate in the blood for levels to rise. But you're saying a single dose or 2 will offset fin/dut sides? This is as per who?
 10/08/2015 10:55 AM
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Billypcuc
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The earliest timepoint collected and reported in the peer-reviewed literature is 7 days. However, I am aware of one group that has reported that the effect is detectable intraday at a conference.
 10/22/2015 05:29 PM
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el_duterino
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Had a look on that Cassopea homepage - the market release target dates are 2018 for the acne product and 2021 for mpb so that's still several solid years to wait

I just started my first CB application yesterday btw - I use 25mg a day in 6mg of Neogenic.

Neo does dissolves CB fine just like ru and I cut my hair super short to make sure the scalp gets most of it so we will see I the coming months how it holds up against ru.
I massage it real hard too so that should work.

I bought my CB from Kane at 165/g so it's about USD 4.15 a day, not too bad.

I was getting sides on ru even at 10mg so the extra cost is well worth a hard dick to me

-------------------------
FIN 98~04
DUT 04~08
DUT + Flutamide & Fluridil ~08
DUT + RU ~09
RU only (20mg to 400mg/d 09~11)
RU+Minox 11~15
RU 20 mg/d (in 6ml Neogenic)
Now:
Adenogen
CB 03-01 25mg/d in 6ml Neo
 10/22/2015 11:23 PM
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ohmyhair
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I really lost any hope on this drug to hit the market, it have been in phase 2 for the last 7 years ! and now we will have to wait anothers 6 years ? what a crap.

-------------------------
I got my Rogain foam on amazon.
I got my avodart on pillsforall.com
 10/23/2015 01:32 AM
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el_duterino
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That's normal - how many drugs do you know are being sold to perfectly healthy young men ?

Anyone could sue them for the smallest issues once on CB so they will make sure they have a solid case before going to market

Fin and minox were already approved as regular drugs before being added to the hair loss market and even then it took extra years

-------------------------
FIN 98~04
DUT 04~08
DUT + Flutamide & Fluridil ~08
DUT + RU ~09
RU only (20mg to 400mg/d 09~11)
RU+Minox 11~15
RU 20 mg/d (in 6ml Neogenic)
Now:
Adenogen
CB 03-01 25mg/d in 6ml Neo
 10/23/2015 01:38 AM
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el_duterino
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Pharma firms prefer genuinely sick persons who will be grateful for a few more years to live even if it means loosing some internal organs or what not and they will be even willing to pay a lot more money for it ...

Risks and returns considerations do not bode well for hair loss drugs

-------------------------
FIN 98~04
DUT 04~08
DUT + Flutamide & Fluridil ~08
DUT + RU ~09
RU only (20mg to 400mg/d 09~11)
RU+Minox 11~15
RU 20 mg/d (in 6ml Neogenic)
Now:
Adenogen
CB 03-01 25mg/d in 6ml Neo
 10/23/2015 03:51 AM
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bej
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Originally posted by: el_duterino
I was getting sides on ru even at 10mg so the extra cost is well worth a hard dick to me


Are you quitting RU? What I was thinking, based on your comment, is that if you feel systemic effects from 10 mg topical RU, that there must certainly be plenty RU there saturating your scalp, so you could probably lower the dose of RU and still have an effective amount on your scalp.
 10/23/2015 04:37 AM
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el_duterino
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Yes lowering the dose may work I know but I still want to give CB a try

-------------------------
FIN 98~04
DUT 04~08
DUT + Flutamide & Fluridil ~08
DUT + RU ~09
RU only (20mg to 400mg/d 09~11)
RU+Minox 11~15
RU 20 mg/d (in 6ml Neogenic)
Now:
Adenogen
CB 03-01 25mg/d in 6ml Neo
 10/23/2015 04:49 AM
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Dench57
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I'm awaiting some CB from a group buy, interested to try it out as I've read it has mild anti-inflammatory properties and people say it helps a lot with the itch.
 10/23/2015 06:34 AM
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Seuxin
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I really don't think neogenic will be a good vehicle for CB...

-------------------------
Best regards,

Seuxin
 10/23/2015 06:43 AM
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el_duterino
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I really don't see why not - on the bald truth forum one guy used CB for a while in regular ethanol and pg 50% wiht good results

Neogenic dissolves the CB completely as well as ru and I know that Neo is very penetrative for ru, I get side effects on it and also read a few other posters getting sides on ru and Neo

-------------------------
FIN 98~04
DUT 04~08
DUT + Flutamide & Fluridil ~08
DUT + RU ~09
RU only (20mg to 400mg/d 09~11)
RU+Minox 11~15
RU 20 mg/d (in 6ml Neogenic)
Now:
Adenogen
CB 03-01 25mg/d in 6ml Neo
 10/23/2015 01:55 PM
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bej
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Originally posted by: el_duterino

I really don't see why not - on the bald truth forum one guy used CB for a while in regular ethanol and pg 50% wiht good results

Neogenic dissolves the CB completely as well as ru and I know that Neo is very penetrative for ru, I get side effects on it and also read a few other posters getting sides on ru and Neo


I thought CB was notorious for being insoluble? If it can dissolve in ethanol/pg, and also neogenic, what was the solubility fuss about?
 10/24/2015 06:48 AM
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el_duterino
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It does take a bit longer to dissolve compared to ru - maybe double the time but it completley
Dissolves in Neogenic - which is mostly ethanol and leaves no residues after the application

-------------------------
FIN 98~04
DUT 04~08
DUT + Flutamide & Fluridil ~08
DUT + RU ~09
RU only (20mg to 400mg/d 09~11)
RU+Minox 11~15
RU 20 mg/d (in 6ml Neogenic)
Now:
Adenogen
CB 03-01 25mg/d in 6ml Neo
 10/24/2015 09:57 AM
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bej
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Originally posted by: el_duterino
It does take a bit longer to dissolve compared to ru - maybe double the time but it completley

Dissolves in Neogenic - which is mostly ethanol and leaves no residues after the application


That's good to know. I had placed it in the "theoretically nice to have, but not practical" bin.
 10/24/2015 10:51 PM
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el_duterino
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I think that CB is going to be better than ru over time - less sides so you can use more and it's going to work better

The reasons why it's going to be more effective is that the total absence of systemic effects will prevent the body from compensating and making more AR and more T as it senses less dht.


This is were RU isn't so great

It's a life saver that we can get our hands on it years before it may hit the market

It's not cheap but not overly expensive either , 5 usd a day isn't the end of the world and who knows how much the real CB - breezula - end product will cost, it could be quite expensive too as they have to recoup R&D costs.

-------------------------
FIN 98~04
DUT 04~08
DUT + Flutamide & Fluridil ~08
DUT + RU ~09
RU only (20mg to 400mg/d 09~11)
RU+Minox 11~15
RU 20 mg/d (in 6ml Neogenic)
Now:
Adenogen
CB 03-01 25mg/d in 6ml Neo

Edited: 10/24/2015 at 11:00 PM by el_duterino
 10/25/2015 10:56 AM
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hairloss18
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Ive been reading up on cb/ breezula and still confused, will this block both types of dht?
 10/25/2015 06:13 PM
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el_duterino
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You seem confused indeed - there are no different types of dht

It's an anti androgen and blocks everything just like any other anti androgen wiht good affinity to the androgen receptor

-------------------------
FIN 98~04
DUT 04~08
DUT + Flutamide & Fluridil ~08
DUT + RU ~09
RU only (20mg to 400mg/d 09~11)
RU+Minox 11~15
RU 20 mg/d (in 6ml Neogenic)
Now:
Adenogen
CB 03-01 25mg/d in 6ml Neo
 10/25/2015 06:38 PM
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jazzb
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Originally posted by: el_duterino

You seem confused indeed - there are no different types of dht



It's an anti androgen and blocks everything just like any other anti androgen wiht good affinity to the androgen receptor


I so love you for being on this forum, you are a truly valuable member .
 10/26/2015 11:40 AM
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hairloss18
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Originally posted by: el_duterino

You seem confused indeed - there are no different types of dht



It's an anti androgen and blocks everything just like any other anti androgen wiht good affinity to the androgen receptor


Did some more research i was confusing different 5 ar types with different types of dht, but i guess what i was getting at is, is this something that can be added to fin for more of an effect since fin only stops 65 percent of dht?
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