Originally posted by: Mopless
Originally posted by: LosingBattle isn't minoxidil a vasodilator? Far as I know, NO. It was thought to be for awhile, but later found out it was not the case. The current theory is it has something to do with opening potassium channels in the hair follicle. Or something like that. Anyone please step it to correct me or if you have something to add.
Minoxidil is a vasodilator. It works, as you said, by opening potassium channels, which causes smooth muscle cells to become hyperpolarized, which makes it more difficult for them to contract. So, if you take a lot of minoxidil, your blood pressure will decrease, and your body will respond by increasing your heart rate. It is unclear why minoxidil regrows hair.
Adenosine, which is used for AV node tachycardias, also opens potassium channels. I wonder if adenosine has ever been studied as a hair loss drug.
Edit: I just looked it up, and apparently adenosine is useful:
"It has been shown that, in Japanese men, adenosine improves androgenetic alopecia due to the thickening of thin hair due to hair follicle miniaturization."
Diazoxide is another hypertension medication that opens potassium channels, but Diazoxide is pretty strong. Much stronger than minoxidil in regards to vasodilation.
02:24 PM by