Climbazole tops newest antifungal trials
Proprietary clinical studies of climbazole, tested in vivo at 0.5% and 1.5% concentrations and compared against common dandruff ingredients as well as placebo, demonstrate dramatic reductions of dandruff. After four weeks, applied three times per week, the score for placebo edges down by just 16 percent, while the score for 0.5% climbazole falls by 49 percent and the score for 1.5% climbazole sinks an impressive 66 percent. Success continues at eight weeks, with the 0.5% climbazole score down by 69 percent and the 1.5% climbazole score down an astounding 82 percent.
A 2001 German study on safety and efficacy of 0.65% climbazole shampoo follows 30 volunteers with moderate to severe seborrheic dermatitis of the scalp. After a one-week washout and four-week course of treatment, clinical evaluation shows a successful reduction in dandruff, skin redness, and itching for 80 percent of the volunteers.
A 1996 German trial compares four dissimilar compounds - climbazole, piroctone olamine, selenium disulfide, and zinc pyrithione - against 22 strains of Malassezia furfur, an anthropophilic yeast associated with dandruff. The mean minimum inhibitory concentration (MIC) for climbazole proves to be just 0.03 m/ml, dramatically less than all others. Zinc pyrithione, the most common ingredient in mass-market dandruff shampoos, requires much greater concentration, 1.0 m/ml. Selenium disulfide requires a full 8.0 m/ml. Piroctone olamine requires 64 m/ml, by far the least active. Dandrene contains both climbazole and ketoconazole.
Another 1996 German study looks at in-vitro MICs for four azole compounds often used in topical therapy - bifonazole, climbazole, clotrimazole, and ketoconazole - against 30 isolates of Malassezia furfur, a lipophilic fungus found on scalps with dandruff. Climbazole and ketoconazole exert similar high antifungal actions, with bifonazole lower and clotrimazole the least active.
A 1997 German investigation compares MICs for climbazole and silver sulphadiazine, an antimicrobial used in veterinary medicine, tested against Malassezia pachydermatis (M canis), a related yeast found in the ears and scalps of our dogs and cats. Each ingredient gets tested against 40 clinical isolates of M pachydermatis. Antifungal action by climbazole proves much higher than the standard silver-sulphadiazine
Id be interested in feedback from anyone who has tried this shampoo?
I have a feeling a Climbazole shampoo would alternate well alongside a PTO shampoo.