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Topic Title: Has anyone heard of Procapil®?
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Created On: 07/27/2006 06:27 AM
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 07/27/2006 06:27 AM
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ltfx
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I did search for it on the forum but couldn't find anything.
What kind of drug is it? is it like minoxidil?

http://www.procapil.com/index.html
http://www.procapil.com/testing.html
 07/27/2006 08:36 AM
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chrome
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itfx,

thanks for posting that. its the first time i have seen this one.




What makes Procapil® work?

Procapil® is a combination of vitaminated biotinyl tripeptide-1 with apigenin and oleanolic acid. Simply put, Procapil® enhances your scalp's production of cellular binding elements that serve two functions; to hold cells together and to facilitate the cellular communication blocked by the effects DHT. It also to increase blood flow within the scalp, allowing more nourishment to reach thinning hair.

Biotinyl Tripepdide-1

A tripeptide-1 is a specialized synthetic molecule containing three amino acid residues - glycerine, histidine and lysine, and is considered a protein derivative. It is used frequently as a skin-conditioning agent for its role in building and preventing the break down of collagen. Biotin is a B vitamin (C10H16N2O3S) essential for cellular growth in the body, as well as the activity of many enzyme systems. It is an ingredient commonly found in many dermatologist-recommended hair loss treatments for its key role in the manufacturing of healthy hair.

The combined properties of these two elements give Procapil® the ability to boost the synthesis of Laminin-5 and Collagen IV at the dermo-epidermal junction. This is an important area of the skin where cells are engaged in the reproductive process- where DHT damage happens.

Laminin-5 is a membrane molecule that provides an attachment surface in a wide variety of cell types- especially epithelial cells (such as those in the skin and scalp). Genetic evidence unequivocally indicates that these cells will adhere to Laminin-5 faster and at a lower coating concentration than any other binding molecules- which means your cells need less of it to do more (and faster) binding. The ability of Procapil® to boost the production of Laminin-5 is part of what helps to firmly anchor your hair, preventing hair loss at the root.

Collagen IV is another component of cellular membranes, serving a similar function to Laminin as an adhesive surface for the growth of epithelial cells. When the Collagen IV meshwork is assembled, it provides a scaffold for the assembly of other membrane components through interactions with substances like Laminin. It plays an important role in the regulation of cell growth, adhesion, and tissue formation. The enhancement of Collagen IV is the other key to the foundation-strengthening abilities of Procapil® which help prevent DHT related hair loss.

Apigenin
Apigenin is a bioflavonoid ( bioflavanoids maintain the walls of small blood vessels) commonly found in leafy plants and vegetables like parsley, artichoke, basil, and celery. Current research trials indicate that it can reduce DNA oxidative damages. It is used in Procapil® for its vasodialative properties, increasing circulation through blood vessels.

Oleanolic acid
Oleanolic acid possesses antioxidant properties which have a beneficial effect on the hair, making it stronger and less susceptible to loss. It's anti inflammatory properties aid in reversing and preventing the damage caused by DHT. Oleanolic acid also has the ability to inhibit 5-alpha-reductase, the enzyme that converts testosterone into dihydrotestosterone.
 07/27/2006 09:06 AM
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chrome
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Stimulation of Hair Growth
Hair follicles incubated for 14 days with biotynil-GHK revealed a 121% increase in growth stimulation.

Clinical Study
Of 35 volunteers with alopecia who applied for the study, 18 were given a hair lotion with 3% Procapil®, to 17 given a placebo. After the course of 4 months, the anagen/telogen ratio was observed and calculated via collected hair samples from both groups. 67% of the Procapil®-using volunteers had their anagen hair number increased by up to 46%.


thats pretty impressive !

could this actually be the elusive topical DHT inhibitor that we have been looking for ?







Edited: 07/27/2006 at 09:07 AM by chrome
 07/27/2006 09:10 AM
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Mojave
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Chrome,

Is that an independent source?

Edit...

Useful looking PDF

Also dug up a product called "Wash DHT" which appears to contain procapil... anyone heard of it?



Edited: 07/27/2006 at 09:21 AM by Mojave
 07/27/2006 09:25 AM
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chrome
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Procapil® is produced by Croda International Plc as an ingredient and sold to any company that wants to use it in one of their formulations.

http://www.croda.co.in/home.aspx?d=content&s=112&r=130

their Procapil PDF is here:
http://www.croda.co.in/download.aspx?s=112&m=doc&id=82




Edited: 07/27/2006 at 09:48 AM by chrome
 07/27/2006 09:33 AM
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DeejayOS
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So why has this been such a secret for so long?
 07/27/2006 09:57 AM
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chrome
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no idea deejay. its certainly an interesting ingredient if the study is to be believed. i have emailed Croda asking more abouit it.


http://www.min.com/Category.asp?idCategory=9

Our innovative hair care line inhibits DHT, one of the scientifically proven causes of hair loss and thinning hair for both men and women. Included in our formulas are ingredients essential for healthy hair and scalp, such as Biotin, Zinc Sulfate and Saw Palmetto. In addition, we actively seek out new and promising ingredients, such as Procapil® and Copper Peptide Y-3 that give our formulations the competitive edge.


biotin,zinc,saw palmetto,copper peptides + procapil.





Edited: 07/27/2006 at 09:59 AM by chrome
 07/27/2006 11:12 AM
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ltfx
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thanks for the response,
yea I really hope it works as they state
I’m considering trying the min product, if the procapil dosen’t work there are other ingredients that might help a little.
I hope the procapil can be added to zix, making the treatment more affordable.


Edited: 07/27/2006 at 11:13 AM by ltfx
 05/14/2007 03:49 AM
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g'day
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I have been using this stuff for a few weeks. What is the current view of copper peptide y-3, and procapil?
 05/14/2007 07:48 AM
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Z79
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I have used it in my minox for almost a year. No improvement whatsoever. Piece of cr*p.
 05/14/2007 08:10 AM
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worriedwoman
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Procapil is in the MIN products, but they don't list what the percentage is. Probably not the 3% used in the study with the great results. Don't know of any other US products containing Procapil, but there are a few Italian ones. I was under the impression that Procapil worked on the same principal as Aminexil--by slowing/reversing fibrosis. Sederma, the French cosmetolgy arm of Croda developed Procapil a few years ago. I wonder why it hasn't found its way into more products by now.





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