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Topic Title: Tamoxifen (wakes up dormant follicles)
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Created On: 10/10/2003 05:04 PM
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 10/10/2003 05:04 PM
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elvis_73_2
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curious...any insights??? (me)


taken from alt.hairloss

I read the below in a September issue of Fitness Rx for Men on page 42.

"
Drug Wakes Dormant Hair Follicles

You're not bald-- you just have a lot of dormant hair follicles that haven't
been awakened yet. University of Michigan Medical Center researchers found
that rubbing a cream containing the cancer-fighting drug Tamoxifen (trade
name Novaldex) on rats just one time activated dormant hair follicles and
increased hair growth. Applying the drug repeatedly caused the rats to
produce too much hair. The treatment worked only in mice that were
genetically altered to create baldness. Bald men have dormant follicles--
healthy, but not producing hair. This research is exciting because it shows
we may be able to wake up these dormant follicles. (Genes Dev., 17:
1219-1224, 2003)
"

Anybody know more about this?

Thanks, John

END
 10/10/2003 05:05 PM
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elvis_73_2
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additional links...

http://www.enetpharmacy.com/prodsearch.asp?q=tamoxifen

http://www.rxsource.com/prodsearch.asp?q=tamoxifen&submit.x=39&submit.y=18

http://www.oneworldrx.com/

http://www.canadian-pharmacy-online.biz/tamoxifen.htm

http://www.viagra.jum-jum.com/tamoxifen.html

http://tamoxifen.newstrove.com/
"M" wrote in message news:
> why don't they just try the novaldex on humans? it couldn't hurt to rub it
> on someone's head ONCE, could it?
>
> m
>
>
> "Ron" wrote in message
> news:
> > John,
> >
> > Here's the abstract to the study. The full study costs $8 and
> > can be ordered on the website (www.genesdev.org). Hope this helps.
> >
> > Cheers,
> > Ron.
> >
> > Vol. 17, No. 10, pp. 1219-1224, May 15, 2003
> >
> >
> > RESEARCH COMMUNICATION
> > Transient activation of -catenin signaling in cutaneous keratinocytes is
> > sufficient to trigger the active growth phase of the hair cycle in mice
> > David Van Mater,1 Frank T. Kolligs,2,6 Andrzej A. Dlugosz,3,5,7 and Eric
> R.
> > Fearon1,2,4,5,8
> >
> > 1 Departments of Human Genetics, 2 Internal Medicine, 3 Dermatology, and 4
> > Pathology, and the 5 Cancer Center, University of Michigan School of
> > Medicine, Ann Arbor, Michigan 48109, USA
> >
> > Wnts have key roles in many developmental processes, including hair
> follicle
> > growth and differentiation. Stabilization of -catenin is essential in the
> > canonical Wnt signaling pathway. We developed transgenic mice expressing a
> > regulated form of -catenin in the skin. Chronic activation of -catenin in
> > resting (telogen) hair follicles resulted in changes consistent with
> > induction of an exaggerated, aberrant growth phase (anagen). Transient
> > activation of -catenin produced a normal anagen. Our data lend strong
> > support to the notion that a Wnt/-catenin signal operating on hair
> follicle
> > precursor cells serves as a crucial proximal signal for the telogen-anagen
> > transition.
> >
> > [Keywords: -catenin; hair follicle; transgenic mouse; anagen; hair cycle
 10/10/2003 08:46 PM
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Luna
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my mother has been taking it for 3 years to help prevent a recurrence of breast cancer...it hasnt done good things for her hair at all. shes thinned considerably the past few years and I believe that is listed as a side effect.
 10/10/2003 10:48 PM
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bnuts
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I think the point though is that the U of Michigan folks applied it topically to rats. I don't know Novaldex personally, but isn't it something that is taken internally? That's the difference.....

-------------------------
Been losing it since age 22. Now a NW 5. Sweet!
 10/10/2003 11:31 PM
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Dean
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Fascinating. Tamoxifen(Nolvadex) would be simple enough to make into a topical. Anyone up for trying it ??

Dean
 10/11/2003 01:16 AM
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voleur
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They are talking about body hair. Hair on mice is the same as human body hair. Of course if you take something like tamoxifen it will grow more body hair but less hair on your head.
 10/11/2003 03:16 AM
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zimmy
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Call me a wuss, but it kinda scares me a bit at the thought of using drugs designed to fight for cancer to try and help your hair.
 10/11/2003 03:35 PM
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norwegian
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wuss.
 10/11/2003 04:12 PM
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Lizzad
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<< wuss. >>



i was waiting for that!

I've taken nolva before as an anti-estrogen. Works well for that purpose. It is also knows for it's endogenous testosterone stimulating properties!
 10/11/2003 07:06 PM
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guillermo
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I Used to treat the gyno that i had and i see no hair regrowth. In fact during that period I started my first massive shed ( the only one I had in more than 5 years of treatment )
 10/12/2003 12:38 AM
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zimmy
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wuss.



Edited: 10/12/2003 at 12:42 AM by Hair Loss Help Moderator
 10/12/2003 12:39 AM
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zimmy
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bleh double post...


Edited: 10/12/2003 at 12:41 AM by Hair Loss Help Moderator
 10/12/2003 07:00 PM
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SteveandSmallville
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"wuss" ? I think you'd have to be absolutely out of your freaking mind to take that stuff. For all you know that stuff could have devastating affects on your body. It's an anti-cancer drug for #$#$ sake ! Really my friend the fact that you're even considering this is scary. Why don't you just wait 2-3-4 maybe 5 years when there'll probably be a cure on the market that'll make us all norwood 0-2's again...
 10/12/2003 07:46 PM
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elvis_73_2
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<< "wuss" ? I think you'd have to be absolutely out of your freaking mind to take that stuff. For all you know that stuff could have devastating affects on your body. It's an anti-cancer drug for #$#$ sake ! Really my friend the fact that you're even considering this is scary. Why don't you just wait 2-3-4 maybe 5 years when there'll probably be a cure on the market that'll make us all norwood 0-2's again... >>


Well no one wants to be a rat I guess...
hairy rat!!!...

Edited: 10/13/2003 at 05:14 AM by Hair Loss Help Moderator
 10/12/2003 08:18 PM
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Lizzad
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<< Norwood 1. Prevention: Zinc/B6 (topically), GSE (oral) >>



Why are you here? Your not balding and your regimen sucks, lol
 10/12/2003 10:19 PM
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pipo!
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What we always forget about these Rat studies is that what may produce hair on the body of a rat may do the opposite to the head of a human. DHT helps human body hair to grow and causes scalp hair to miniturize. The body of a rat may be more closely related to that of human body hair.

Remember the study that showed topical estrogen to cause rat body hair to fall out? Well, estrogen has been shown to be protective of the human scalp follicle androgen receptors. awww rats!

pipo

-------------------------
Lee's xandrox 15 w/o ppg (at night)
Fin 1.25mg
1% Niz 3xweek
Nan0 everyday
Folligen lotion mixed with Nano conditioner am (leave in)
Folligen lotion and cream at night before minox
 10/13/2003 12:27 AM
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guillermo
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"Why are you here? Your not balding and your regimen sucks, lol"
May be he just feel lonely ..after all this is a good site to meet people
 10/13/2003 08:31 AM
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SteveandSmallville
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I'm here so I don't end up looking like you lizzad ...
 10/13/2003 08:53 AM
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zimmy
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Why are you here? Your not balding and your regimen sucks, lol. May be he just feel lonely ..after all this is a good site to meet people

This is a good site to meet bald men, so i hear.
 10/13/2003 08:05 PM
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Slick420
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Seeing as I take Nolvadex at the end of my steroid cycles, I wouldnt have a problem rubbing it on if someone could tell me how to turn it into a practical application for my head.
I have yet to hear any negative feedback from any guys on the bodybuilding sites regarding serious dangerous associated with its use. just my 2 cents

Edited: 10/13/2003 at 08:06 PM by Hair Loss Help Moderator
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