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Topic Title: resveratrol - rubbish for hair
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Created On: 03/03/2009 01:54 PM
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 03/03/2009 01:54 PM
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Eagle
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Papers on the topic.
=========================================
Arch Pharm Res. 2008 Jan;31(1):83-7.Links
trans-Resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo.
Shin S, Jeon JH, Park D, Jang MJ, Choi JH, Choi BH, Joo SS, Nahm SS, Kim JC, Kim YB.
College of Veterinary Medicine, Chungbuk National University, Heungdeok-gu, Cheongju, Chungbuk 361-763, Korea.

"resveratrol did elicit an increase in blood testosterone concentration, testicular sperm counts and epididymal sperm motility by 51.6%, (smift notes: study in rabbits, Dosage 50mg/kg) 15.8% and 23.3%, respectively, without influence on sperm deformity. In conclusion, we propose that resveratrol has a positive effect on male reproductive function by triggering a penile erection, as well as enhancing blood testosterone levels, testicular sperm counts, and epididymal sperm motility.


Bolloxxx. Ive been on resveratrol for bout 6 weeks. my hair has shed quite alot. i couldnt work it out. i wanted to take this as its supposed to be good for you, though it seems its rubbish for ur hair.



 03/03/2009 01:55 PM
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Eagle
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Testosterone increase reported by supplement manufacturer Patrick Arnold (possible vested interest)
"one of our guys had an increase of 1100% in total test after 4 weeks while taking 1000mg res / 1000mg quercetin combination. one guy was around 70% the other one closer to 200%."

and this too
 03/03/2009 02:36 PM
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grove
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so what you got boners all day long?

 03/03/2009 02:47 PM
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Eagle
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yeah i ve been pretty horny
 03/03/2009 03:59 PM
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ThickofIT
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report seems to disagree:

Immortalisation and characterisation of balding and non-balding dermal papilla cell lines and their response to oxidative stress. Adiam W Bahta, Dermatology (QMUL), London, UK The dermal papilla (DP) expresses androgen receptors and is known to control normal hair growth. The paradox of androgen action in human hair growth is well established but the molecular mechanisms in hair follicles are poorly understood. DP cells derived from frontal (balding) human scalp hair follicles (BDPC) are used to study Androgenetic alopecia. However, cultured BDPC are very difficult to obtain, grow very slowly in vitro and have a limited life span of 2-6 passages before they senescence (see other abstract). We have recently shown that BDPC express senescence-associated beta galactosidase activity at PH-6. Moreover, stress induced premature senescence was induced with more prominent characteristic behaviour in BDPC than non balding DPC (NBDPC) after exposure to sub-cytotoxic levels of H2O2. However, the limited life span of BDPC represents a substantial obstacle for biochemical analysis, genetic manipulation and screens. We therefore, generated immortalized balding and non-balding human DP cells (IBDPC, INBDPC) by ectopic expression of human telomerase. The IBDPC have undergone more than 90 passages without showing any phenotypic changes. As with the primary DPC, the IBDPC maintained their aggregating characteristics and expressed wnt7a, wnt3a, androgen receptor and 5 alpha reductase type 2 mRNA. We established an in vitro co-culture system by growing IBDPC and INBDPC with keratinocytes (KC) to study the androgen effects in hair follicles. Androgen suppressed the growth of KC when grown with IBDPC and this could be partially reversed using a neutralising antibody to TGF-beta1. In addition we have also observed that IBDPC retains increased sensitivity towards H2O2 than INBDPC cell lines. Therefore, immortalised DP cell lines show similar characteristics to primary DPC and they will be of major help to us in our attempt to understand the actions of androgens on hair growth and enable the development of better treatment for androgen dependent hair disorders. ------------------------------------------------------------ Resveratrol only does 3 important things:


 03/03/2009 04:53 PM
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underpressure
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i honestly think that any pill/supplement that increases libido is bad for hair. i took collagen ,my libido was in overdrive but my hair went to shit. sounds like the same type of thing with resveratrol.
 03/03/2009 05:40 PM
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chris09
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You know what also causes an increase in testosterone? Propecia! Avoid it at all costs if you want to save your hair!

Interesting study report, but it's still hard to say whether resveratrol has an overall negative or positive effect on hair, just because it increases testosterone (if it indeed does increase T -- I think that's the only study I've seen reporting a resveratrol-T link.)

 03/03/2009 06:13 PM
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CheckingIn
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Originally posted by: Eagle



"resveratrol did elicit an increase in blood testosterone concentration, testicular sperm counts and epididymal sperm motility by 51.6%, (smift notes: study in rabbits, Dosage 50mg/kg) 15.8% and 23.3%, respectively, without influence on sperm deformity. In conclusion, we propose that resveratrol has a positive effect on male reproductive function by triggering a penile erection, as well as enhancing blood testosterone levels, testicular sperm counts, and epididymal sperm motility.




Bolloxxx. Ive been on resveratrol for bout 6 weeks. my hair has shed quite alot. i couldnt work it out. i wanted to take this as its supposed to be good for you, though it seems its rubbish for ur hair.


Quite frankly, there might not be anything that you can take orally that saves your hair. However, Resveratrol is supposed to be fantastic for preventing aging and making one feel better. At 50mg/kg as for the study, a 150 pound person would have to be taking 3,400mg/day to get the same amount in the study.

 07/27/2009 04:41 PM
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jbj
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That's interesting, I've also been on Resveratrol for about 6 weeks and I have begun to worry as I'm seeing more and more of my scalp through my hair. I have a question though. After reading this webpage:

http://www.hairloss-research.o...eResveratrol11-07.html

about the Italian hair growth study in which Resveratrol is a central part, I began to be optimistic that the hair loss I'm experiencing may be the sign that it's working to regrow hair. The reason I'm hoping this is because when I used minoxidil a few years ago I remember that this happened then too and I read that it was a sign that the follicles were shedding their hairs to make room for new ones. The hair lost from the minoxidil seemed to grow back and arguably thicker.
Does anybody think this may be what's happening with the Resveratrol?
 07/27/2009 05:03 PM
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Moximus
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I've read alot regarding curcumin, in fact I have an entire book if anyone wants to contact me I can send it to you.

It has plenty of properties that make sense as a hair growth promoting agent. It's an anti-oxidant, anti-inflammatory, EGFR-inhibitor, and a few other things that have escaped me. With that being said it isnt ideal because it also inhibits the beta-catenin Wnt pathway and is also a strong inhibitor of angiogenesis (albeit noone knows if this only occurs in cancerous cells). Those 2 things are crucial for anagen hair growth.

It would be hard to tell if the positives outway the negatives, and there hasnt been any large scale in vivo studies.
 07/27/2009 10:05 PM
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StandStrong
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Immortal Hair recommends both these supps too.

Eagle hair improvemen was only note when using BOTH Curcumin and resveratrol.
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