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Topic Title: Adenosine for Hair Growth
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Created On: 12/23/2004 12:50 AM
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 12/23/2004 12:50 AM
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Maxwell
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Joined: 12/17/2004

Guys,

The developers of Amashsiho (Shiseido) are bringing out a topical Adenosine in March of next year for MPB.

Here is their study - very very interesting.

It would seem that 2005 may hold a lot of promise for the treatment of AGA. I do not think these are snake oils either. What I do believe is that the general internet hair loss community are a lot wiser than a few years ago so they are a more educated buyer. Reading a lot of these abstracts I believe that many companies know this and at least try to support their claims with some kind of study.

Time will tell how effective these are. If not too expensive I do believe that with a multifaceted approach the use of prescription drugs may not always be necessary.

Here is the study:

A Randomized Trial of Adenosine In Androgenetic Alopecia.

Watanabe Dermatological Clinic, Tokyo, Japan. etc. al. June, 2004.

Objective: Adenosine upregulates the expression of fibroblast growth factor
7 (FGF7) and vascular endothelial growth factor (VEGF) on cultured dermal
papilla cells via adenosine receptors. We therefore speculated that
adenosine stimulates growth of hair fiber due to the action of FGF7 and VEGF
for epithelial cells in hair follicles. In this study, we performed a
clincial trial to investigate the efficacy and safety of adenosine in hair
loss associated with androgenetic alopecia (AGA).

Methods: A hundred and four volunteers with AGA were registered in a
randomized double-blind trial that used an adenosine (0.75%) topical lotion
or niacin amide (0.1%) topical lotion twice daily for 6 months. Efficacy was
evaluated by investigator assessments of change in global scalp coverage,
change in the ratio of vellus-like (under 40 um in diameter) and thick hairs
(not less than 60 um or 80 um in diameter), and hair density, in vertex.

Results: Fifty-one of 52 adenosine-treated subjects and 50 of 52 niacin
amide-treated subjects completed the 6-month study. For global improvement,
adenosine was significantly superior to niacin amide. Treatment with either
lotion resulted in a significantly decreased ratio of vellus-like hair and
also significantly increased the ratio of thick hair, but did not change the
hair density. Regarding the increase in the ratio of thick hair, adenosine
was significantly superior to niacin amide. Adverse effects were not found.

Conclusion: In men with AGA, adenosine increased hair growth and thickened
vellus-like hair without side effects. It would appear that the efficacy of
hair growth results from the effects of FGF7 and VEGF which are stimulated
by activation of adenosine receptors on dermal papilla cells.

Maxwell


Edited: 12/23/2004 at 05:27 AM by Maxwell
 12/23/2004 06:36 AM
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fifty
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So this stuff thickens vellus hairs but didn't increase hair density. Doesn't sound too promising to me. I think it's funny that no one can come up with a drug that's decent for hairloss without stumbling upon it (minoxidil for blood pressure and proscar for BPH both had hair growth as "side effects").
 12/23/2004 08:31 AM
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xoxopao
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Joined: 11/16/2004

well, that would be great for me, as all I want is thick my temples, which are very thin by now.. =D
 12/23/2004 10:43 AM
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Maxwell
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Joined: 12/17/2004

It is a very positive conclusion.

"Treatment with either
lotion resulted in a significantly decreased ratio of vellus-like hair and
also significantly increased the ratio of thick hair, but did not change the
hair density. Regarding the increase in the ratio of thick hair, adenosine
was significantly superior to niacin amide. Adverse effects were not found."

I think it is an exciting conclusion, not necessarily the cure that we are looking for but at least it is a soon to be released product that will at least offer some hope (I am referring to Adenogen).

It may increase scalp coverage for some people.

I think all we will have here is "another minox" but it offers an alternative/addtion to those that have plataued on minox or those who did not respond to it or could not tolerate it.

For those of you who are into self experiments here is a link to topical niacin amide (which did also improve the ratio of vellus to thick hairs) - http://www.google.co.uk/search?q=cacheQm6OstpiSIJ:tsangenterprise.com/acnecare.htm+topical+niacin+amide&hl=en

And no I do not sell the stuff, there are probably a million other places to purchase it.

Maxwell.
 12/23/2004 10:43 AM
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Maxwell
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Edited: 12/23/2004 at 10:43 AM by Maxwell
 12/23/2004 11:10 AM
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crazydiamond
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Joined: 01/04/2002

Wonder why they used 0.1% Niacin Amide as the comparison. That acne site has a 5% topical version, wonder how soon it will be before someone gives that a try? It also contains Aloe Vera/Emu and jojoba all of which have been tried topically here, so would be an interesting combo.
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